Ocean with island above the surface and octopus submerged below, suggesting that there’s more to some cancers than meets the eye


Look below the surface to find out what’s driving the tumor

TRK* fusion proteins are often a primary oncogenic driver across multiple tumors in adults and children1,2

  • In TRK fusion cancer, the NTRK a gene fuses with an unrelated gene, causing overexpression of the TRK protein2-4
  • NTRK gene fusions may be mutually exclusive of other known oncogenic drivers5,6
  • The presence of TRK proteins has been associated with more aggressive cancer in some tumor types, highlighting an unmet medical need among TRK fusion cancer patients7-9
The only way to find NTRK gene fusions is to test for them10

*TRK, tropomyosin receptor kinase.
aNTRK, neurotrophic receptor tyrosine kinase.

References: 1. Okimoto RA, Bivona TG. Cancer Discov. 2016;6(1):14-16. 2. Vaishnavi A, Le AT, Doebele RC. TRKing down an old oncogene in a new era of targeted therapy. Cancer Discov. 2015;5(1):25-34. 3. Amatu A, Sartore-Bianchi A, Siena S. ESMO Open. 2016;1(2):e000023. 4. Kumar-Sinha C, Kalyana-Sundaram S, Chinnaiyan AM. Landscape of gene fusions in epithelial cancers: seq and ye shall find. Genome Med. 2015;7:129. doi:10.1186/s13073-015-0252-1. 5. Stransky N, Cerami E, Schalm S, Kim JL, Lengauer C. The landscape of kinase fusions in cancer. Nat Commun. 2014;5:4846. doi:10.1038/ncomms5846. 6. Prasad ML, Vyas M, Horne MJ, et al. NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States. Eur J Cancer. 2016;122(7):1097-1107. 7. Lange AM, Lo H-W. Inhibiting TRK proteins in clinical cancer therapy. Cancers. 2018;10(4):E105. doi:10.3390/cancers10040105. 8. Musholt TJ, Musholt PB, Khaladj N, Schulz D, Scheumann GFW, Klempnauer J. Prognostic significance of RET and NTRK1 rearrangements in sporadic papillary thyroid carcinoma. Surgery. 2000;128(6):984-993. 9. Okamura K, Harada T, Wang S, et al. Expression of TrkB and BDNF is associated with poor prognosis in non-small cell lung cancer. Lung Cancer. 2012;78(1):100-106. 10. Hechtman JF, Benayed R, Hyman DM, et al. Pan-trk immunohistochemistry is an efficient and reliable screen for the detection of NTRK fusions. Am J Surg Pathol. 2017;41(11):1547-1551.