TRK* fusion proteins are often a primary oncogenic driver across multiple tumors in adults and children^1,2

In TRK fusion cancer, the NTRK ^a gene fuses with an unrelated gene, causing overexpression of the TRK protein^2-4
NTRK gene fusions may be mutually exclusive of other known oncogenic drivers^5,6
The presence of TRK proteins has been associated with more aggressive cancer in some tumor types, highlighting an unmet medical need among TRK fusion cancer patients^7-9

THE ONLY WAY TO FIND NTRK GENE FUSIONS IS TO TEST FOR THEM¹⁰

Take a deep dive into the science behind TRK fusion cancer

^*TRK, tropomyosin receptor kinase.

^aNTRK, neurotrophic receptor tyrosine kinase.

References: 1. Okimoto RA, Bivona TG. Cancer Discov. 2016;6(1):14-16. 2. Vaishnavi A, Le AT, Doebele RC. TRKing down an old oncogene in a new era of targeted therapy. Cancer Discov. 2015;5(1):25-34. 3. Amatu A, Sartore-Bianchi A, Siena S. ESMO Open. 2016;1(2):e000023. 4. Kumar-Sinha C, Kalyana-Sundaram S, Chinnaiyan AM. Landscape of gene fusions in epithelial cancers: seq and ye shall find. Genome Med. 2015;7:129. doi:10.1186/s13073-015-0252-1. 5. Stransky N, Cerami E, Schalm S, Kim JL, Lengauer C. The landscape of kinase fusions in cancer. Nat Commun. 2014;5:4846. doi:10.1038/ncomms5846. 6. Prasad ML, Vyas M, Horne MJ, et al. NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States. Eur J Cancer. 2016;122(7):1097-1107. 7. Lange AM, Lo H-W. Inhibiting TRK proteins in clinical cancer therapy. Cancers. 2018;10(4):E105.doi:10.3390/cancers10040105. 8. Musholt TJ, Musholt PB, Khaladj N, Schulz D, Scheumann GFW, Klempnauer J. Prognostic significance of RET and NTRK1 rearrangements in sporadic papillary thyroid carcinoma. Surgery. 2000;128(6):984-993. 9. Okamura K, Harada T, Wang S, et al. Expression of TrkB and BDNF is associated with poor prognosis in non-small cell lung cancer. Lung Cancer. 2012;78(1):100-106. 10. Hechtman JF, Benayed R, Hyman DM, et al. Pan-trk immunohistochemistry is an efficient and reliable screen for the detection of NTRK fusions. Am J Surg Pathol. 2017;41(11):1547-1551.

THERE’S MORE TO SOME CANCERS THAN MEETS THE EYE

TRK FUSION CANCER

LOOK BELOW THE SURFACE TO FIND OUT WHAT’S DRIVING THE TUMOR

TRK* fusion proteins are often a primary oncogenic driver across multiple tumors in adults and children^1,2

THE ONLY WAY TO FIND NTRK GENE FUSIONS IS TO TEST FOR THEM¹⁰

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THERE’S MORE TO SOME CANCERS THAN MEETS THE EYE

TRK FUSION CANCER

LOOK BELOW THE SURFACE TO FIND OUT WHAT’S DRIVING THE TUMOR

TRK* fusion proteins are often a primary oncogenic driver across multiple tumors in adults and children1,2

THE ONLY WAY TO FIND NTRK GENE FUSIONS IS TO TEST FOR THEM10

TRK* fusion proteins are often a primary oncogenic driver across multiple tumors in adults and children^1,2

THE ONLY WAY TO FIND NTRK GENE FUSIONS IS TO TEST FOR THEM¹⁰